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Updated: May 24, 2026
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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
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Gingival diffuse large B-cell lymphoma: report of 2 cases
1Dept. of Pathology, The Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.
Summary
Diffuse large B-cell lymphoma (DLBCL) of the oral gums is rare and often misdiagnosed. This study reviews 2 new cases and 21 prior reports to improve understanding and diagnosis of this condition.
Area of Science:
- Oral oncology
- Hematology
- Pathology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma, but its occurrence in the oral gingiva is exceptionally rare.
- Gingival DLBCL presents diagnostic challenges due to its rarity and potential for misdiagnosis as more common oral lesions.
Observation:
- Two cases of primary oral gingival DLBCL are presented, detailing their unique clinicopathological characteristics.
- A comprehensive literature review of 21 previously reported gingival DLBCL cases (2008-2023) was conducted.
Findings:
- Analysis of these cases highlights key diagnostic features and potential pitfalls in differentiating gingival DLBCL from other oral pathologies.
- The study underscores the importance of considering DLBCL in the differential diagnosis of persistent or unusual gingival lesions.
Implications:
- Improved diagnostic accuracy for oral gingival DLBCL can lead to timely and appropriate treatment, potentially improving patient outcomes.
- This review contributes to a better understanding of this rare entity, aiding clinicians in recognizing and managing gingival DLBCL effectively.
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