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Risk factors for recurrence in patients with hormone receptor-positive/human epidermal growth factor receptor
Naoki Miyazaki1, Toshiki Iwasaki1, Hitomi Sakai2
1Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
Current Medical Research and Opinion
|April 10, 2024
Summary
This systematic review quantifies recurrence risk factors for hormone receptor-positive/human epidermal growth factor receptor 2-negative early breast cancer in Japan. Key factors include lymph node metastasis, large tumor size, and high histological grade.
Area of Science:
- Oncology
- Clinical Research
- Epidemiology
Background:
- Clinicopathological factors guide perioperative therapy for breast cancer recurrence risk.
- Risk factors for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) early breast cancer in Japan are known but not systematically quantified.
- A quantitative summary of these risk factors is needed for treatment decisions.
Purpose of the Study:
- To systematically review and meta-analyze risk factors for recurrence in HR+/HER2- early breast cancer in Japan.
- To provide a quantitative summary of these risk factors for improved clinical guidance.
- To identify prognostic factors for overall survival and breast cancer-specific survival.
Main Methods:
- Systematic literature review and meta-analysis of studies from MEDLINE, Embase, Cochrane CENTRAL, and Japan Medical Abstract Society databases.
- Inclusion of 42 eligible publications.
- Primary outcome: relapse-free or disease-free survival (RFS/DFS); Secondary outcomes: overall survival and breast cancer-specific survival (BCSS).
Main Results:
- Lymph node metastasis, large tumor size, high histological grade, and high nuclear grade are significant risk factors for RFS/DFS.
- Lymph node metastasis, large tumor size, and high histological grade are also risk factors for overall survival.
- High progesterone status may be a favorable prognostic factor for BCSS.
Conclusions:
- The identified risk factors for HR+/HER2- early breast cancer recurrence in Japan are consistent with previous reports.
- This study provides a quantitative summary of these risk factors, aiding in risk stratification and treatment planning.
- Further research may refine prognostic models for this patient population.
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