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Related Experiment Video

Updated: Jun 28, 2025

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
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Conjugal Synucleinopathies: A Clinicopathologic Study.

Charles H Adler1, Matthew Halverson2, Nan Zhang3

  • 1Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|April 10, 2024
PubMed
Summary
This summary is machine-generated.

Human transmission of synucleinopathy between spouses is unlikely. A study of 90 couples found only 16 instances where both partners had synucleinopathy, such as Parkinson's disease or dementia with Lewy bodies.

Keywords:
Alzheimer's diseaseParkinson's diseaseconjugaldementia with Lewy bodiesneuropathology

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Area of Science:

  • Neuroscience
  • Pathology
  • Epidemiology

Background:

  • Preclinical studies suggest alpha-synuclein can spread via cell-to-cell transmission.
  • The potential for human-to-human transmission of synucleinopathy remains unknown.

Purpose of the Study:

  • To investigate the occurrence of synucleinopathy in autopsied conjugal couples.
  • To assess the possibility of synucleinopathy transmission between spouses.

Main Methods:

  • Neuropathological examination of 90 deceased conjugal couples.
  • Categorization of findings into Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease with Lewy bodies (ADLB), incidental Lewy body disease (ILBD), or no Lewy bodies.

Main Results:

  • Out of 90 couples, 32 had no Lewy bodies.
  • 42 couples had one spouse with a synucleinopathy (10 PD, 3 DLB, 13 ADLB, 16 ILBD).
  • 16 couples had both spouses with a synucleinopathy, with varied combinations of PD, DLB, and ADLB.

Conclusions:

  • Synucleinopathy transmission between spouses appears unlikely.
  • This study of 90 conjugal couples provides evidence against significant human-to-human transmission of synucleinopathies.