Associations between vitamin D status, VDR gene polymorphisms and echocardiographic markers in Polish patients with

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Mohamed Abouzid1,2, Paweł Burchardt3,4, Leonid Kagan5

  • 1Department of Physical Pharmacy & Pharmacokinetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.

Future Cardiology
|April 10, 2024
PubMed

Insights

This study explored vitamin D metabolites and VDR gene variations in cardiovascular disease patients. Certain VDR gene types were linked to lower aortic valve pressure gradients and hypertension predictors.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Nutritional Science

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality worldwide.
  • Vitamin D and its receptor (VDR) gene polymorphisms are implicated in various physiological processes, including cardiovascular health.
  • Understanding the interplay between vitamin D metabolism, VDR genetics, and CVD markers is crucial for potential therapeutic strategies.

Purpose of the Study:

  • To investigate the associations between vitamin D metabolites and VDR gene polymorphisms (ApaI, TaqI, BsmI, FokI).
  • To correlate these genetic and metabolic factors with echocardiographic markers in patients with cardiovascular disease.
  • To identify potential predictors of hypertension within this patient cohort.

Main Methods:

  • Echocardiographic assessment using tissue Doppler techniques in 42 CVD patients.
  • Genotyping of VDR gene polymorphisms (ApaI, TaqI, BsmI, FokI) via PCR-restriction fragment length polymorphism analysis.
  • Quantification of vitamin D metabolites using a validated ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method.

Main Results:

  • Patients with the ApaI-GT genotype showed a lower aortic valve pressure gradient compared to ApaI-TT carriers.
  • Body Mass Index (BMI), ApaI-GT, TaqI-TC genotypes, aortic arch diameter, and maximal pressure gradient were significant univariate predictors of hypertension.
  • These findings suggest a relationship between specific VDR genotypes and cardiovascular parameters.

Conclusions:

  • A potential association exists between VDR gene polymorphisms and cardiovascular function in patients with CVD.
  • Specific VDR genotypes may influence hemodynamic parameters like aortic valve pressure gradients.
  • Further research is warranted to elucidate the precise mechanisms linking VDR genetics, vitamin D status, and cardiovascular outcomes.

Keywords:
25-hydroxyvitamin D3-epi-hydroxyvitamin Dcardiovascular diseasehypertensionvitamin D receptor

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