The Relationship between the Systemic Immune-Inflammation Index and Ischemia with Non-Obstructive Coronary Arteries...

Area of Science:

• Cardiology
• Inflammation markers
• Coronary artery disease

Background:

• Ischemia with non-obstructive coronary artery (INOCA) involves coronary microvascular dysfunction or vasospasm, often seen in women.
• The systemic immune-inflammation index (SII), calculated as platelet × neutrophil/lymphocyte ratio, is a novel marker for adverse outcomes in coronary artery disease (CAD).

Purpose of the Study:

• To investigate the association between INOCA and the systemic immune-inflammation index (SII).
• To evaluate SII as a potential inflammatory marker for predicting INOCA.

Main Methods:

• A study included 424 patients: 212 with INOCA and 212 controls.
• Peripheral venous blood samples were collected before coronary angiography to measure SII and hematological parameters.
• Statistical significance was set at p<0.05.

Main Results:

• The optimal SII cut-off for INOCA prediction was 153.8, with 44.8% sensitivity and 78.77% specificity (AUC: 0.651).
• SII demonstrated a significantly higher predictive value for INOCA compared to lymphocyte, neutrophil, and platelet counts alone.
• The Area Under the Curve (AUC) for SII was 0.651, significantly outperforming individual components.

Conclusions:

• Elevated SII levels are independently associated with the presence of INOCA.
• SII can serve as an accessible indicator to supplement traditional, costly methods for INOCA prediction.