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A cubic DNA nanocage probe for in situ analysis of miRNA-10b in tumor-derived extracellular vesicles
Xiaoyan Sun1, Yafei Chen1, Haiyan Li1
1Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning, 110819, P. R. China. chenml@mail.neu.edu.cn.
Abstract:
A cubic DNA nanocage probe is able to enter EVs derived from MDA-MB-231 cells and react with miRNA-10b. The probe-loaded EVs were employed to monitor the process of entry of miRNA-10b into MCF-10A cells, allowing visualization of EV-mediated intercellular communication of miRNA-10b between the cancer cells.

