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In Situ Bioprinting: Process, Bioinks, and Applications.
Pooja Jain1, Himanshu Kathuria2, Seeram Ramakrishna3
1Faculty of Dentistry, National University of Singapore, Singapore 119805, Singapore.
ACS Applied Bio Materials
|April 10, 2024
Summary
In situ bioprinting offers personalized regenerative medicine by directly depositing biomaterials for patient-specific tissue fabrication. This review explores techniques, bioinks, and challenges for clinical translation.
Area of Science:
- Regenerative Medicine
- Biomedical Engineering
- Materials Science
Background:
- Traditional tissue engineering faces limitations in scaffold fabrication and clinical accessibility.
- In situ bioprinting emerges as a promising alternative for on-site, patient-specific tissue regeneration.
Purpose of the Study:
- To review in situ bioprinting techniques, bioink materials, and their properties.
- To discuss challenges and future trends for clinical translation of in situ bioprinting.
Main Methods:
- Review of current literature on in situ bioprinting technologies.
- Analysis of bioink compositions and critical material properties.
- Discussion of application across various tissue types (skin, bone, cartilage, muscle).
Main Results:
- In situ bioprinting enables precise, on-demand fabrication of complex tissue constructs.
- Bioinks are crucial for cell viability and functional tissue development.
- The technology aligns with precision medicine principles for personalized treatments.
Conclusions:
- In situ bioprinting presents a significant advancement for personalized regenerative medicine.
- Overcoming current challenges is key to accelerating clinical translation.
- Future trends focus on optimizing bioinks and printing strategies for broader healthcare applications.
