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A New Murine Model of Endovascular Aortic Aneurysm Repair
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The ascending aortic aneurysm: When to intervene?
Emile Saliba1, Ying Sia1, Annie Dore2
1Hôtel Dieu de Montreal, CHUM - Centre Hospitalier de l'Université de Montréal, 3840 St Urbain St, Montreal, QC H2W 1T8, Canada.
International Journal of Cardiology. Heart & Vasculature
|April 10, 2024
Summary
Thoracic ascending aorta aneurysms (TAA) are a significant cause of adult mortality. Early recognition, close follow-up, and timely prophylactic therapy can significantly reduce TAA-related morbidity and mortality.
Area of Science:
- Cardiovascular Medicine
- Vascular Surgery
Background:
- Thoracic ascending aorta aneurysms (TAA) represent a critical cause of mortality in adults.
- TAA is less studied compared to abdominal aortic aneurysms (AAA).
Purpose of the Study:
- To elucidate the etiology, pathophysiology, and diagnosis of TAA.
- To summarize recent advancements in TAA management.
Main Methods:
- Comprehensive literature search of PubMed and MEDLINE (1980-2014).
- Keywords included: ascending aorta aneurysm, thoracic aneurysms, Marfan syndrome, bicuspid aortic valve, familial thoracic syndrome, aortic dissection, aorta imaging, and aortic aneurysm guidelines.
Main Results:
- TAA is a highly lethal condition.
- Prophylactic surgery and diligent follow-up significantly decrease TAA morbidity and mortality.
- Recent years have seen substantial progress in understanding TAA's pathological mechanisms.
Conclusions:
- TAA is often asymptomatic, necessitating early detection.
- Close patient monitoring is crucial for timely preventive and prophylactic interventions.
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