Related Experiment Video
Updated: Jun 28, 2025
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
68 Ga-DOTATATE and 18 F-FDG PET Imaging of a Rare Chordoid Meningioma With Intracranial Recurrence and Extracranial
Mathew V Smith1, Harrison J Lang1, Kliment Donev2
1From the Department of Radiology, Mayo Clinic Arizona.
Abstract:
Chordoid meningiomas, rare meningioma variants, are characterized by their histopathological features and clinical behavior resembling that of other chondroid/myxoid neoplasms. We present a case of pathology-proven chordoid meningioma imaged with both 68 Ga-DOTATATE and 18 F-FDG PET images during a complicated postoperative course with multiple episodes of local recurrence and, ultimately, extracranial metastasis. This case underscores the aggressive behavior of chordoid meningiomas while highlighting how molecular imaging plays an important role in clinical monitoring and guidance of management.
Insights
Chordoid meningiomas are rare tumors with aggressive behavior. Molecular imaging, using 68 Ga-DOTATATE and 18 F-FDG PET scans, aids in monitoring and managing these challenging cases.
Area of Science:
- Neuro-oncology
- Molecular Imaging
- Pathology
Background:
- Chordoid meningiomas are rare meningioma variants with distinct histopathological and clinical features.
- Their behavior can mimic other chondroid/myxoid neoplasms, posing diagnostic challenges.
Observation:
- A case of pathology-proven chordoid meningioma is presented.
- The patient underwent imaging with both 68 Ga-DOTATATE and 18 F-FDG PET during a complex postoperative period.
- Multiple local recurrences and eventual extracranial metastasis were observed.
Findings:
- The case illustrates the aggressive clinical course of chordoid meningiomas.
- Molecular imaging effectively monitored disease progression and recurrence.
Implications:
- This case highlights the utility of 68 Ga-DOTATATE and 18 F-FDG PET in managing chordoid meningiomas.
- Molecular imaging is crucial for guiding treatment and monitoring outcomes in aggressive meningioma variants.
![Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58641.jpg&w=3840&q=50)