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Updated: Jun 28, 2025

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Published on: December 26, 2016

In Vivo Assays for Amyloid-Related Diseases.

Alba Espargaró^1,2, Irene Álvarez-Berbel¹, Maria Antònia Busquets^1,2

¹1Department of Pharmacy and Pharmaceutical Technology and Department of Physical Chemistry, School of Pharmacy, University of Barcelona, Barcelona, Spain;

Annual Review of Analytical Chemistry (Palo Alto, Calif.)

|April 10, 2024

Summary

Amyloid-related diseases like Alzheimer's and Parkinson's involve protein aggregates. This review outlines in vivo analytical methods crucial for understanding these diseases and developing new treatments in animal models.

Keywords:

amyloid amyloid-related diseases conformational diseases neurodegenerative diseases protein misfolding

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Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease

Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease

Published on: April 19, 2021

Area of Science:

Neuroscience and Pharmacology
Biochemistry and Molecular Biology

Background:

Amyloid-related diseases, including Alzheimer's and Parkinson's, stem from abnormal amyloid fibril accumulation.
Animal models are crucial for studying disease mechanisms and therapeutic development, despite ethical considerations.

Purpose of the Study:

To categorize and review primary analytical methods used in in vivo assays for amyloid-related diseases.
To emphasize the importance of these methods in advancing disease understanding and therapy development.

Main Methods:

Review of standardized analytical techniques applied in animal models.
Categorization of methods based on their application in assessing amyloid fibril formation, propagation, and drug pharmacokinetics/pharmacodynamics.

Main Results:

Identified a range of analytical techniques essential for in vivo studies.
Highlighted the standardization of methods across different animal models.

Conclusions:

Standardized analytical methods in animal models are vital for understanding amyloid-related diseases.
These methods are indispensable for the discovery and development of effective therapies for neurodegenerative disorders.