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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Bioluminescent Bacterial Imaging In Vivo
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Progress of engineered bacteria for tumour therapy.

Xue Xia1, Jing-Wen Zhang1, Bing Zhao1

  • 1Jiangxi Key Laboratory of Translational Cancer Research, NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Jiangxi Clinical Research Center for Cancer, Nanchang, Jiangxi 330029, PR China; College of Chemistry and Bio-engineering, Yichun University, Yichun 336000, PR China.

International Immunopharmacology
|April 10, 2024
PubMed
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Genetically engineered bacteria show promise in tumor therapy by enhancing targeting and penetration. This review assesses their development, integration with other treatments, and clinical trial status, while discussing current challenges.

Keywords:
BacteriaGenetically engineered bacteriaTargeted therapyTumor

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Area of Science:

  • Oncology
  • Biotechnology
  • Microbiology

Background:

  • Novel therapeutic modalities, drug delivery, and tumor immune escape are key challenges in cancer treatment.
  • Bacterial therapeutics offer potential for preventing tumor spread and recurrence, alone or with traditional therapies.
  • Genetic engineering has significantly improved bacteria's tumor targeting and penetration capabilities.

Purpose of the Study:

  • To provide an overview and assessment of advancements in tumor therapy using genetically engineered bacteria.
  • To cover the development of engineered bacteria, their integration with other therapeutic techniques, and clinical trial progress.
  • To discuss current limitations and challenges in applying engineered bacteria for tumor treatment.

Main Methods:

  • Review of recent advancements in genetically engineered bacteria for cancer therapy.
  • Analysis of integration strategies with existing therapeutic modalities.
  • Assessment of the current landscape of clinical trials involving engineered bacteria.

Main Results:

  • Genetic engineering enhances bacterial targeting and penetration for improved tumor therapy.
  • Engineered bacteria show potential in combination therapies and reducing immune escape.
  • Clinical trials are underway, indicating progress in translating research to practice.

Conclusions:

  • Genetically engineered bacteria represent a promising frontier in tumor therapy.
  • Further research is needed to overcome limitations and challenges for widespread clinical application.
  • Integration with other treatments and addressing immune escape are critical for maximizing efficacy.