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  3. Predictors Of Germline Genetic Testing Referral And Completion In Ovarian Cancer Patients At A Comprehensive Cancer Center.
  1. Home
  3. Predictors Of Germline Genetic Testing Referral And Completion In Ovarian Cancer Patients At A Comprehensive Cancer Center.

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Predictors of germline genetic testing referral and completion in ovarian cancer patients at a Comprehensive Cancer

Katherine W Saylor1, Elizabeth Q Fernandes2, Michael Adams3

  • 1Department of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia, PA, United States of America.

Gynecologic Oncology
|April 10, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Germline genetic testing in ovarian cancer is influenced by referral and oncologist practices. Efforts to improve access and reduce turnaround time are ongoing.

Keywords:
Access barriersGermline testingProvider variationReferral

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Area of Science:

  • Oncology
  • Genetics
  • Health Services Research

Background:

  • Germline genetic testing is crucial for ovarian cancer management and hereditary cancer risk assessment.
  • Understanding factors influencing testing referral and completion is essential for equitable patient care.

Purpose of the Study:

  • To identify predictors of germline genetic testing referral and completion in newly diagnosed ovarian cancer patients.
  • To examine the impact of geographic social deprivation and oncologist practices on testing.
  • To analyze the time interval from diagnosis to genetic testing results.

Main Methods:

  • Retrospective chart review of ovarian cancer patients diagnosed between 2014-2019.
  • Multivariable regression analysis to identify factors associated with referral, completion, and time to results.
  • Inclusion of Social Deprivation Index (SDI) at the ZIP code level.

    • Main Results:

    • 67% of patients were referred for genetic counseling and 62% completed germline testing.
    • Referral probability was higher for patients with lower Social Deprivation Index (SDI) scores.
    • Significant variation in referral rates was observed across oncologists.
    • The median time from diagnosis to test results was 137 days, with a trend towards decreasing interval over time.

    Conclusions:

    • Germline testing rates are relatively high, but disparities exist based on patient and oncologist factors.
    • Reducing the time from diagnosis to results is a positive trend.
    • Strategies like automated referrals, remote services, and cost reduction should be explored to improve access and efficiency.