Risk factors for tumor enlargement in low-risk papillary thyroid microcarcinoma patients: a systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Younger age and higher thyroid-stimulating hormone (TSH) levels are key risk factors for tumor growth in patients with low-risk papillary thyroid microcarcinoma (PTMC) under active surveillance. Pregnancy may also increase the risk of tumor enlargement.
Area Of Science
- Endocrinology
- Oncology
- Medical Surveillance
Background
- Current guidelines lack specific screening protocols for tumor growth in low-risk papillary thyroid microcarcinoma (PTMC) patients undergoing active surveillance (AS).
- Identifying risk factors for tumor enlargement is crucial for optimizing AS protocols and patient management.
Approach
- A comprehensive meta-analysis was conducted by searching PubMed and Embase databases for relevant studies up to January 10th, 2024.
- Eleven high-quality studies were included, with risk factors for tumor enlargement analyzed using Newcastle-Ottawa Scale (NOS) and Review Manager 5.4 software.
- Pooled risk ratios (RRs) were calculated to assess the association between various factors and tumor growth in 8880 participants.
Key Points
- Tumor enlargement in low-risk PTMC was significantly associated with younger age (RR = 2.32) and higher serum thyroid-stimulating hormone (TSH) levels (RR = 2.28).
- Pregnancy emerged as a potential risk factor for tumor enlargement (RR = 2.54).
- Factors such as sex, initial tumor size, and Hashimoto's thyroiditis did not show a significant association with tumor growth.
Conclusions
- Younger age and elevated serum TSH levels are identified as significant risk factors for tumor enlargement in patients with low-risk PTMC.
- Pregnancy is a suspected risk factor requiring further investigation.
- These findings can inform the development of more targeted surveillance strategies for PTMC.
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