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Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Updated: Jun 28, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Engineering approaches to manipulate osteoclast behavior for bone regeneration.

Xin Cheng¹, Wenzhi Tian², Jianhua Yang³

¹Department of Stomatology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, 1098 Xueyuan Road, Shenzhen 518055, Guangdong Province, China.

Materials Today. Bio

|April 11, 2024

Summary

Osteoclasts, traditionally known for bone breakdown, also significantly impact bone formation. Engineering strategies now aim to harness osteoclasts for enhanced bone repair and regeneration.

Keywords:

Biomaterials Bone coupling Bone regeneration Drug delivery Osteoclasts

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Last Updated: Jun 28, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

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Area of Science:

Biomaterials Science
Cell Biology
Regenerative Medicine

Background:

Osteoclasts' role extends beyond bone resorption to influencing bone formation.
Emerging research explores osteoclast manipulation for therapeutic bone regeneration.
Understanding osteoclast-mediated bone metabolism is crucial for developing new treatments.

Purpose of the Study:

To review the mechanisms of osteoclast influence on bone metabolism.
To explore engineering strategies for targeting osteoclasts in bone repair.
To identify limitations and future directions in osteoclast-targeted bone regeneration.

Main Methods:

Comprehensive literature review of osteoclast function and engineering approaches.
Analysis of bioactive material modifications for osteoclast modulation.
Evaluation of localized drug delivery and exogenous cell strategies targeting osteoclasts.

Main Results:

Osteoclasts play a dual role in bone resorption and formation.
Engineering strategies can modulate osteoclast activity for bone repair.
Bioactive materials, drug delivery, and cell therapies show promise.

Conclusions:

Targeting osteoclasts offers a novel therapeutic avenue for bone regeneration.
Further research is needed to overcome current limitations in osteoclast manipulation.
Integrating biological and material cues is key for future advancements in bone repair.