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Updated: Jun 28, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
CSDE1: a versatile regulator of gene expression in cancer
Annagiulia Ciocia1,2, Neus Mestre-Farràs1, Ignacio Vicent-Nacht1,2
1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr Aiguader 88, Barcelona 08003, Spain.
Abstract:
RNA-binding proteins (RBPs) have garnered significant attention in the field of cancer due to their ability to modulate diverse tumor traits. Once considered untargetable, RBPs have sparked renewed interest in drug development, particularly in the context of RNA-binding modulators of translation. This review focuses on one such modulator, the protein CSDE1, and its pivotal role in regulating cancer hallmarks. We discuss context-specific functions of CSDE1 in tumor development, its mechanisms of action, and highlight features that support its role as a molecular adaptor. Additionally, we discuss the regulation of CSDE1 itself and its potential value as biomarker and therapeutic target.
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