Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

327
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
327
Lineage Commitment01:21

Lineage Commitment

3.0K
Commitment is the  process whereby stem cells:
3.0K
Stem Cell Culture01:17

Stem Cell Culture

5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.2K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia.

Blood·2026
Same author

comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

Cell stem cell·2026
Same author

Do Surveillance Tests for Relapse Improve Survival After Chemotherapy for Paediatric Acute Leukaemia? A Systematic Review.

Pediatric blood & cancer·2025
Same author

Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia.

Blood·2025
Same author

Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.

Blood·2025
Same author

PROM1/CD133 marks a proliferative stem cell-like population of blasts in KMT2A rearranged infant ALL.

Blood advances·2025
Same journal

A mechanistic study on the enhanced antihypertensive effects of a <i>Dendrobium officinale</i> compound combined with Western antihypertensive drugs in spontaneously hypertensive rats based on metabolomics and gut microbiota analysis.

Frontiers in cell and developmental biology·2026
Same journal

From pathophysiology to therapy: molecular mechanisms of stem cell and extracellular vesicle-mediated repair in diabetic peripheral neuropathy.

Frontiers in cell and developmental biology·2026
Same journal

The gut-brain axis: mechanisms linking intestinal dysbiosis with stroke.

Frontiers in cell and developmental biology·2026
Same journal

Towards a bioengineered airway: advances in tracheal tissue engineering and biofabrication.

Frontiers in cell and developmental biology·2026
Same journal

Targeting nuclear receptors in muscular dystrophies and regenerative myogenesis.

Frontiers in cell and developmental biology·2026
Same journal

Risk-centered benchmarking of large language models for AI-enabled counseling in chronic autoimmune thyroid eye disease.

Frontiers in cell and developmental biology·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2025

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.0K

Aberrant stem cell and developmental programs in pediatric leukemia.

Rebecca E Ling1, Joe W Cross1, Anindita Roy1,2,3

  • 1Department of Paediatrics, University of Oxford, Oxford, United Kingdom.

Frontiers in Cell and Developmental Biology
|April 11, 2024
PubMed
Summary
This summary is machine-generated.

Hematopoiesis, the process of blood cell formation, can be disrupted in leukemia. Hijacked stem cell programs in leukemia drive disease progression and treatment resistance.

Keywords:
development genesfetal oncogenesgene regulationleukemiastem cells

More Related Videos

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.0K
Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
10:25

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

9.4K

Related Experiment Videos

Last Updated: Jun 28, 2025

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.0K
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.0K
Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
10:25

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

9.4K

Area of Science:

  • Hematology
  • Cancer Biology
  • Stem Cell Biology

Background:

  • Hematopoiesis is essential for lifelong blood cell production, originating from hematopoietic stem cells.
  • Leukemia arises from disruptions in normal hematopoiesis, characterized by uncontrolled proliferation and blocked differentiation.
  • Cancer cells, including leukemia blasts, often co-opt normal stem cell programs for survival and proliferation.

Purpose of the Study:

  • To understand how aberrant stem cell programs contribute to leukemia development and maintenance.
  • To identify therapeutic targets by investigating the role of hijacked stem cell programs in leukemia.
  • To explore the developmental origins of leukemia, particularly the role of fetal stem cell profiles.

Main Methods:

  • Analysis of gene expression patterns in leukemia cells.
  • Comparison of leukemic stem cell programs with normal hematopoietic stem cell programs.
  • Investigation of fetal stem cell signatures in pediatric leukemia.

Main Results:

  • Leukemic cells exhibit stem cell-like properties, enabling proliferation and treatment evasion.
  • Aberrant fetal stem cell programs are implicated in the maintenance of certain leukemias.
  • Hijacked stem cell programs drive aberrant gene expression crucial for leukemia biology.

Conclusions:

  • Understanding the co-option of stem cell programs in leukemia is key to developing novel therapies.
  • Targeting aberrant fetal stem cell programs presents a promising therapeutic strategy for leukemia.
  • Deciphering the interplay between stem cell biology and leukemia pathogenesis can improve patient treatment outcomes.