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Effect of smoking-related features and 731 immune cell phenotypes on esophageal cancer: a two-sample and mediated

Kaiqi Yang1, Shaoya Li1, Yuchen Ding1

  • 1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.

Frontiers in Immunology
|April 11, 2024
PubMed
Summary

Smoking increases esophageal cancer risk, with specific immune cells like CD62L plasmacytoid dendritic cells and CD27 in CD20-CD38-B cells potentially mediating this effect. Never smoking is protective against esophageal cancer.

Keywords:
Mendelian randomizationesophageal cancerimmune cell phenotypesmediation effectsmoking-related features

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