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Clinical effectiveness of microporous polysaccharide hemospheres in mastectomy for patients with breast cancer
Yoshiaki Shinden1,2, Yuki Nomoto1,3, Ayako Nagata1
1Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragoka, Kagoshima-City, Japan.
Background:
Microporous polysaccharide hemospheres (MPH) are hydrophilic particles administered to reduce the incidence of seroma after mastectomy, but their clinical effectiveness remains controversial. Because a previous randomized, controlled study in a small cohort could not demonstrate the effectiveness of MPH in breast surgery, we evaluated their effectiveness in surgery for breast cancer in a larger cohort.
Methods:
Medical records of 352 patients who underwent total mastectomy for breast cancer were retrospectively reviewed. Clinical data were compared between 126 patients who received MPH during surgery (MPH group) and 226 who did not (control group) according to surgical procedures. Patients were significantly older in the MPH group than in the control group because of selection bias, but other factors, such as body mass index and number of dissected lymph nodes, did not differ between groups.
Results:
When analyzed by use of axillary manipulation, the drain placement period and drainage volume were significantly less in the MPH group than in the control group for patients with mastectomy and sentinel lymph node biopsy. Only drainage volume was significantly less in the MPH group for patients with mastectomy and axillary lymph node dissection. The frequency of total postoperative complications, such as seroma requiring puncture, did not differ between groups.
Conclusions:
Use of MPH may decrease the postoperative drainage volume and drain placement period in mastectomy for patients with breast cancer.
Insights
Microporous polysaccharide hemospheres (MPH) may reduce fluid drainage and drain duration after mastectomy for breast cancer. Further research is needed to confirm MPH effectiveness in reducing seroma formation.
Area of Science:
- Oncology
- Surgical Innovation
- Biomaterials
Background:
- Microporous polysaccharide hemospheres (MPH) are hydrophilic particles used to reduce seroma after mastectomy.
- Previous studies on MPH effectiveness in breast surgery yielded controversial results.
- This study aimed to evaluate MPH effectiveness in a larger cohort of breast cancer patients.
Purpose of the Study:
- To assess the clinical effectiveness of microporous polysaccharide hemospheres (MPH) in reducing postoperative complications after mastectomy for breast cancer.
- To compare outcomes between patients who received MPH and a control group.
Main Methods:
- Retrospective review of medical records of 352 patients undergoing total mastectomy for breast cancer.
- Comparison of clinical data between 126 patients who received MPH and 226 control patients.
- Analysis stratified by surgical procedures, including sentinel lymph node biopsy and axillary lymph node dissection.
Main Results:
- Patients receiving MPH were older due to selection bias, but other factors were comparable.
- MPH group showed significantly reduced drain placement period and drainage volume in specific surgical subgroups (mastectomy with SLNB, mastectomy with ALND).
- No significant difference in the overall frequency of postoperative complications, including seroma requiring puncture, between groups.
Conclusions:
- Microporous polysaccharide hemospheres (MPH) show potential in decreasing postoperative drainage volume and drain placement duration in mastectomy patients.
- MPH may be a beneficial adjunct in specific breast cancer surgical procedures.
- Further investigation is warranted to fully elucidate the role of MPH in preventing seroma formation.
