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Related Experiment Video

Updated: Jun 28, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

A Case-Control Study Utilizing Red Cell Distribution Width as a Bio-Inflammatory Marker in Pre-eclampsia.

Khushboo Singhal¹, Shweta Gupta², Sunita Tiwari³

¹Department of Physiology, Subharti Medical College, Meerut, IND.

|April 11, 2024

Summary

Red cell distribution width (RDW) can help diagnose pre-eclampsia (PE). Higher RDW levels were significantly associated with PE, showing diagnostic accuracy in this study.

Keywords:

biomarker hematological analyzer preeclampsia pregnancy red cell distribution width

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Area of Science:

Obstetrics and Gynecology
Hematology
Clinical Diagnostics

Background:

Pre-eclampsia (PE) is a pregnancy complication marked by high blood pressure and proteinuria after 20 weeks.
Early detection and diagnosis of PE are crucial for maternal and fetal well-being.

Purpose of the Study:

To evaluate the effectiveness of red cell distribution width (RDW) as a diagnostic marker for pre-eclampsia.
To determine the diagnostic accuracy of RDW in distinguishing between pre-eclampsia cases and normotensive controls.

Main Methods:

A case-control study involving 70 pregnant women (35 PE cases, 35 controls).
Venous blood samples were analyzed using a semi-automated hematological analyzer to measure RDW.
Receiver operating curve (ROC) analysis was performed to assess diagnostic accuracy.

Main Results:

Women with pre-eclampsia exhibited significantly higher RDW levels compared to healthy controls (p=0.004).
RDW demonstrated significant diagnostic accuracy (AUC=0.71, p=0.004) with a cut-off of >=18.25, showing 80% sensitivity and 71.4% specificity.

Conclusions:

Red cell distribution width (RDW) is a cost-effective and accessible biomarker from complete blood counts.
RDW shows potential as a valuable tool for the prediction and diagnosis of pre-eclampsia.