Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synthetic polymers as drugs.

A C Albertsson, L G Donaruma, O Vogl

    Annals of the New York Academy of Sciences
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Synthetic polymers were modified with biologically active compounds like bithionol, primaquine, and vinylsalicylic acids to create novel antibacterial and antimalarial materials. These advanced polymers show potential for targeted drug delivery and controlled degradation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Finalizing the properties of porous scaffolds of aliphatic polyesters through radiation sterilization.

    Biomaterials·2006
    Same author

    Great advantages in using a natural rubber instead of a synthetic SBR in a pro-oxidant system for degradable LDPE.

    Biomacromolecules·2001
    Same author

    Sterilization, storage stability and in vivo biocompatibility of poly(trimethylene carbonate)/poly(adipic anhydride) blends.

    Biomaterials·2000
    Same author

    Encapsulation of rotavirus into poly(lactide-co-glycolide) microspheres.

    Journal of controlled release : official journal of the Controlled Release Society·1999
    Same author

    Bioactive heparin surfaces from derivatization of polyacrylamide-grafted LLDPE.

    Biomaterials·1996
    Same author

    Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: in vivo degradation behaviour.

    Journal of biomaterials science. Polymer edition·1994
    Same journal

    Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

    Annals of the New York Academy of Sciences·2026
    Same journal

    Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

    Annals of the New York Academy of Sciences·2026
    Same journal

    Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

    Annals of the New York Academy of Sciences·2026
    Same journal

    LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

    Annals of the New York Academy of Sciences·2026
    Same journal

    Polyrhythm Perception and Production: A Scoping Review.

    Annals of the New York Academy of Sciences·2026
    Same journal

    DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

    Annals of the New York Academy of Sciences·2026
    See all related articles

    Area of Science:

    • Polymer Chemistry
    • Medicinal Chemistry
    • Materials Science

    Background:

    • Biologically active compounds offer therapeutic potential but require suitable delivery systems.
    • Synthetic polymers can be functionalized to incorporate and release active pharmaceutical ingredients.
    • Developing biodegradable polymers with controlled release properties is crucial for biomedical applications.

    Purpose of the Study:

    • To synthesize and characterize novel polymers incorporating biologically active compounds.
    • To investigate the degradation properties and biological activity of these functionalized polymers.
    • To explore the potential of these materials in drug delivery and antimicrobial applications.

    Main Methods:

    • Incorporation of bithionol as bisphenol monomers into polyesters, polyphosphates, and phosphonates.

    Related Experiment Videos

  • Synthesis of copolycarbonates and polyurethanes using bithionol derivatives.
  • Reaction of primaquine and amantadine with isocyanates and polyepichlorohydrin.
  • Polymerization and copolymerization of vinylsalicylic acids to create polymeric antibacterials.

    • Main Results:

    • Bithionol-based copolycarbonates exhibited controlled degradation (approx. 1% per day) under physiological conditions.
    • Primaquine-containing polymers were synthesized via biuret formation and nucleophilic substitution.
    • Vinylsalicylic acid polymers and copolymers demonstrated selective antibacterial activity, tunable by comonomer choice or derivatization.

    Conclusions:

    • Synthetic polymers can be effectively functionalized with biologically active agents to create advanced materials.
    • Degradable polymers with incorporated drugs show promise for controlled release applications.
    • Tailored polymer structures offer selectivity in biological activity, paving the way for targeted therapeutics.