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A new simple controlled release delivery system.

G G Allan, C Balaban, J Dutkiewicz

    Annals of the New York Academy of Sciences
    |January 1, 1985
    PubMed
    Summary
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    Researchers created low-cost cellulose composites from never-dried wood pulp. These novel materials effectively entrap and release biologically active compounds, showing potential for drug delivery and agricultural applications.

    Area of Science:

    • Materials Science
    • Biotechnology
    • Chemical Engineering

    Background:

    • Chemical pulping of wood yields water-saturated hollow fibers with microporous cell walls.
    • These never-dried fibers offer a cost-effective and sustainable starting material.
    • Conventional methods for incorporating active agents into cellulose often involve harsh conditions or drying steps.

    Purpose of the Study:

    • To develop a novel method for creating cellulose-based composites containing biologically active agents.
    • To investigate the release characteristics of these composites.
    • To demonstrate the versatility of the method using different active compounds.

    Main Methods:

    • Wood pulp fibers were chemically pulped and kept hydrated.
    • Never-dried fibers were impregnated with solutions of acetylsalicylic acid (analgesic), alpha-naphthylacetic acid (growth stimulant), or 2,4-dichlorophenoxyacetic acid (herbicide).

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  • Impregnated fibers were dried to form collapsed cellulose ribbons containing the entrapped agents.

    • Main Results:

    • The process successfully yielded cellulose ribbons with entrapped biologically active chemicals.
    • In vitro and in vivo evaluations demonstrated controlled release of the incorporated agents.
    • The composites showed efficacy for delivering an analgesic, a plant growth stimulant, and a herbicide.

    Conclusions:

    • Never-dried wood pulp fibers provide a viable, low-cost platform for creating functional cellulose composites.
    • This method offers a simple and effective way to load and control the release of diverse biologically active compounds.
    • These cellulose composites hold promise for applications in controlled drug delivery and agriculture.