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The Role of Immune Cells in DKD: Mechanisms and Targeted Therapies

Qiu-Yue Peng1,2,3, Ying An1,2,3, Zong-Zhe Jiang1,2,3

  • 1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.

Journal of Inflammation Research
|April 11, 2024
PubMed

Insights

Diabetic kidney disease (DKD) involves complex interactions between immune and kidney cells. Understanding these interactions can reveal new therapeutic targets for DKD treatment.

Area of Science:

  • Nephrology
  • Immunology
  • Genomics

Background:

  • Diabetic kidney disease (DKD) is a significant complication of diabetes, contributing to mortality.
  • Immune cell and cytokine dysregulation accelerates DKD progression.
  • Cell-to-cell interactions within the kidney are crucial for DKD pathogenesis.

Purpose of the Study:

  • To review molecular mechanisms of immune and renal cell interactions in DKD.
  • To discuss recent advances in single-cell technology and bioinformatics for DKD research.
  • To identify immune cells as potential therapeutic targets for DKD.

Main Methods:

  • Literature review of molecular mechanisms in DKD.
  • Analysis of recent studies utilizing single-cell technologies.
  • Examination of bioinformatics approaches in DKD research.

Main Results:

  • Detailed summary of molecular interactions between immune and renal cells in DKD.
  • Highlighting the impact of immune dysregulation on kidney pathology.
  • Integration of single-cell and bioinformatics findings.

Conclusions:

  • Immune cell interactions are central to DKD development and progression.
  • Single-cell technologies and bioinformatics offer novel insights into DKD.
  • Targeting immune cells presents a promising strategy for future DKD therapies.
Keywords:
bioinformatics analysisdiabetic kidney diseaseimmune cellssingle-cell analysis

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