Safety evaluation of an extension of use of the food enzyme triacylglycerol lipase from the non-genetically modified Mucor circinelloides strain AE-LMH
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Summary
This summary is machine-generated.The food enzyme triacylglycerol lipase, produced by Mucor circinelloides, is safe for expanded use in five food manufacturing processes. EFSA
Area Of Science
- Food enzyme safety assessment
- Microbiology and biotechnology
- Toxicology and risk assessment
Background
- Triacylglycerol lipase (EC 3.1.1.3) is a food enzyme produced by Mucor circinelloides.
- A previous safety evaluation by EFSA concluded no safety concerns for its use in three food manufacturing processes.
- The applicant sought to extend the enzyme's use to two additional food manufacturing processes.
Purpose Of The Study
- To update the safety evaluation of the food enzyme triacylglycerol lipase.
- To assess the safety of the enzyme for use in a total of five food manufacturing processes.
- To determine if the expanded use of the enzyme presents any safety concerns.
Main Methods
- Dietary exposure estimation for the food enzyme-total organic solids (TOS) in European populations.
- Calculation of the margin of exposure (MOE) by comparing estimated exposure to the no observed adverse effect level (NOAEL).
- Review of previously submitted data and updated exposure assessments.
Main Results
- Estimated dietary exposure to triacylglycerol lipase-TOS was up to 0.845 mg TOS/kg body weight per day.
- A margin of exposure (MOE) of at least 928 was derived.
- The NOAEL from the previous evaluation was 784 mg TOS/kg body weight per day.
Conclusions
- The updated safety evaluation considered the revised intended conditions of use.
- The derived margin of exposure (MOE) indicates a sufficient safety margin.
- EFSA concluded that the food enzyme triacylglycerol lipase does not give rise to safety concerns under the revised intended conditions of use.
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