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Assessing and Comparing Potential Allergenicity of Two Partially Hydrolyzed Whey-Based Formulas for Infants: A

Lijuan Sun1, Shiwen Han1, Sufang Duan2

  • 1College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, P. R. China.

Molecular Nutrition & Food Research
|April 11, 2024
PubMed

Insights

Partially hydrolyzed whey-based formulas (PHF-Ws) show high intolerance rates in infants with cow's milk allergy (CMA). These formulas may not be suitable for Chinese infants and children diagnosed with CMA.

Area of Science:

  • Food Science
  • Allergology
  • Pediatric Nutrition

Background:

  • Hydrolyzed infant formulas are recommended when breast milk is insufficient.
  • Cow's milk allergy (CMA) is a common concern in infants.
  • Partially hydrolyzed whey-based formulas (PHF-Ws) are often used as alternatives.

Purpose of the Study:

  • To assess and compare the allergenicity of two PHF-Ws.
  • To evaluate the immune response to PHF-Ws in infants with CMA.

Main Methods:

  • Utilized LC-MS/MS technology to analyze peptide distribution.
  • Examined the immunoreactivity of two PHF-Ws using serum from 50 Chinese infants (0-2 years) with CMA.
  • Assessed peptide molecular weights and residual allergenic epitopes.

Main Results:

  • Significant variations in immune responses were observed between the two PHF-Ws.
  • Factors influencing immune response include degree of hydrolysis, protein source, peptide size (<5 kDa), and epitope differences.
  • High intolerance rates (>10%) were noted for both PHF-Ws in the study cohort.

Conclusions:

  • The tested PHF-Ws exhibit substantial intolerance among infants with CMA in China.
  • PHF-Ws may not be a suitable primary alternative for infants and children suffering from CMA in this population.
  • Further research into specific formula compositions and their allergenic potential is warranted.
Abstract

Keywords:
cow's milk allergypartially hydrolyzed whey‐based formulapeptidomicssensitization assessment

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