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Bioinspired Soft Robot with Incorporated Microelectrodes
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Semiphysical Design Concept for Developing Miniaturized Microrobots In Vivo.

Tiange Zhang1, Xiaoshuai Liu2, Haifeng Qin1

  • 1Guangdong Provincial Key Laboratory of Nanophotonic Manipulation, Institute of Nanophotonics, Jinan University, Guangzhou 511443, China.

Nano Letters
|April 11, 2024
PubMed
Summary

Researchers developed a novel semiphysical microrobot (SPM) that uses light beams to minimize size while retaining function. This innovation enables advanced in vivo biomedical applications like targeted thrombus removal and biosensing-guided microsurgery.

Keywords:
biosensingmicrorobotmicrosurgeryoptical manipulationupconversion nanoparticles

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Area of Science:

  • Biomedical Engineering
  • Robotics
  • Nanotechnology

Background:

  • Microrobot miniaturization is essential for in vivo applications but challenging to achieve without compromising functionality.
  • Existing microrobots face limitations in size reduction while maintaining complex biomedical tasks.
  • A novel design approach is needed to overcome the physical constraints of miniaturized biomedical robots.

Purpose of the Study:

  • To propose a semiphysical design concept for miniaturized biomedical microrobots.
  • To demonstrate a microrobot design that minimizes physical size by incorporating invisible components like light beams.
  • To maintain and enhance biomedical functions despite significant size reduction.

Main Methods:

  • Developed a semiphysical microrobot (SPM) concept utilizing light beams as primary components.
  • Constructed an SPM comprising a main light beam for actuation, a light-responsive microparticle for recognition, and an auxiliary light beam for surgical functions.
  • Employed light-responsive materials and precise beam manipulation for microrobot control and operation.

Main Results:

  • Successfully constructed a functional semiphysical microrobot (SPM) based on the proposed design.
  • Demonstrated the SPM's capabilities in actuation, biosensing, and microsurgery.
  • Successfully applied the SPM for thrombus elimination in branch vessels, stratified removal of multilayer thrombus, and biosensing-guided microsurgery.

Conclusions:

  • The semiphysical design concept offers a viable solution for developing highly miniaturized biomedical microrobots.
  • Incorporating invisible components like light beams effectively minimizes microrobot size without sacrificing essential biomedical functions.
  • This approach provides new insights and potential for advancing the field of miniaturized biomedical robotics for in vivo applications.