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Spermidine-Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds
Qianqian Wu1, Runjiao Yang1, Wenxuan Fan1
1Key Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 11, 2024
Summary
This study introduces a spermidine-functionalized hydrogel (DN-SPD) that reduces inflammation and promotes tissue regeneration. This injectable biomaterial accelerates healing for acute and diabetic wounds by modulating the immune response.
Area of Science:
- Biomaterials Science
- Immunology
- Regenerative Medicine
Background:
- Inflammation significantly impacts tissue regeneration outcomes.
- Spermidine possesses known immunomodulatory properties.
- Developing advanced biomaterials is crucial for effective wound healing.
Purpose of the Study:
- To develop an injectable double network hydrogel functionalized with spermidine (DN-SPD).
- To evaluate the immunomodulatory and regenerative capabilities of DN-SPD in vivo.
- To assess the potential of DN-SPD for treating acute and diabetic wounds.
Main Methods:
- Fabrication of a double network hydrogel with dynamic imine and photo-crosslinked bonds.
- In situ printing and photo-crosslinking of injectable single network hydrogels.
- In vivo animal experiments comparing DN-SPD with a control (DN-DETA) hydrogel.
- Assessment of inflammatory markers, macrophage polarization, and wound healing efficacy.
Main Results:
- DN-SPD hydrogel exhibited favorable mechanical properties and tissue adhesion.
- DN-SPD significantly reduced inflammation and reactive oxygen species compared to DN-DETA.
- DN-SPD promoted macrophage polarization towards the regenerative M2 phenotype.
- Accelerated and more natural healing of acute and diabetic wounds was observed with DN-SPD.
Conclusions:
- Local administration of spermidine via DN-SPD hydrogel effectively attenuates foreign body reactions.
- DN-SPD hydrogel offers a promising strategy for treating chronic refractory wounds by modulating the immune response.
- Spermidine-functionalized hydrogels represent a novel approach for enhancing tissue regeneration and wound healing.
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