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Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications
Zhaotian Feng1,2,3, Muhua Luan2,3, Wenshuai Zhu3
1Department of Medical Laboratory, Shandong Second Medical University, Weifang, 261053, People's Republic of China.
Abstract:
Gastrointestinal cancer is a significant global health burden, necessitating the development of novel therapeutic strategies. Emerging evidence has highlighted the potential of targeting ferritinophagy as a promising approach for the treatment of gastrointestinal cancer. Ferritinophagy is a form of selective autophagy that is mediated by the nuclear receptor coactivator 4 (NCOA4). This process plays a crucial role in regulating cellular iron homeostasis and has been implicated in various pathological conditions, including cancer. This review discusses the molecular mechanisms underlying ferritinophagy and its relevance to gastrointestinal cancer. Furthermore, we highlight the potential therapeutic implications of targeting ferritinophagy in gastrointestinal cancer. Several approaches have been proposed to modulate ferritinophagy, including small molecule inhibitors and immunotherapeutic strategies. We discuss the advantages and challenges associated with these therapeutic interventions and provide insights into their potential clinical applications.
Insights
Targeting ferritinophagy, a cellular process regulating iron, shows promise for gastrointestinal cancer treatment. This review explores ferritinophagy
Area of Science:
- Oncology
- Cellular Biology
- Autophagy Research
Background:
- Gastrointestinal cancer presents a significant global health challenge.
- Novel therapeutic strategies are urgently needed.
- Ferritinophagy, a selective autophagy process, is emerging as a potential therapeutic target.
Purpose of the Study:
- To review the molecular mechanisms of ferritinophagy.
- To discuss the relevance of ferritinophagy in gastrointestinal cancer.
- To explore therapeutic strategies targeting ferritinophagy for gastrointestinal cancer.
Main Methods:
- Literature review of ferritinophagy mechanisms.
- Analysis of ferritinophagy's role in gastrointestinal cancer.
- Evaluation of therapeutic approaches targeting ferritinophagy.
Main Results:
- Ferritinophagy is mediated by nuclear receptor coactivator 4 (NCOA4).
- This process is crucial for cellular iron homeostasis and implicated in cancer.
- Targeting ferritinophagy offers potential therapeutic benefits for gastrointestinal cancers.
Conclusions:
- Modulating ferritinophagy presents a promising avenue for gastrointestinal cancer therapy.
- Small molecule inhibitors and immunotherapies are potential strategies.
- Further research is needed to explore clinical applications and overcome challenges.
