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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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American Radium Society Appropriate Use Criteria for Unresectable Locally Advanced Non-Small Cell Lung Cancer.

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This guideline provides evidence-based recommendations for managing unresectable locally advanced non-small cell lung cancer (LA-NSCLC). It addresses controversies in radiation and systemic therapies to optimize patient care.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Clinical Practice Guidelines

Background:

  • Locally advanced non-small cell lung cancer (LA-NSCLC) treatment has evolved over 5 decades.
  • Controversies persist regarding optimal radiation and systemic therapy application in LA-NSCLC.

Purpose of the Study:

  • To establish evidence-based guidelines for unresectable LA-NSCLC management.
  • To provide consensus recommendations for clinical practice.

Main Methods:

  • Systematic literature review with evidence ratings.
  • Consensus-based modified Delphi approach for treatment appropriateness.
  • Vetting by ARS AUC Executive Committee and public comment period.

Main Results:

  • Standard care for good prognosis LA-NSCLC: concurrent chemoradiation with consolidation durvalumab.
  • Intensity-modulated radiotherapy recommended for planning and delivery.
  • Flexible fractionation schedules available for patients with poor performance status.

Conclusions:

  • The ARS AUC provides evidence-based guidance for unresectable LA-NSCLC.
  • Optimizes multidisciplinary care for challenging patient cases.
  • Addresses complex salvage therapy for local recurrence.