Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Anxiety: Overview

Anxiety: Overview

Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Generalized Anxiety Disorder

Generalized Anxiety Disorder

Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells.

International journal of molecular medicine·2026

Same author

Metformin at environmental relevant concentration induced glucose metabolism disorder in frog: Integrated microstructural, physiological, transcriptomic, and metabolomic insight.

Journal of hazardous materials·2026

Same author

Large language models for systematic reviews were reported to perform well but rarely with verifiable safeguards: a cross-sectional study.

Journal of clinical epidemiology·2026

Same author

Design and methodology of the AI-empowered Clinical Evidence for Integrated Chinese-Western Medicine (ACE-iMed) platform.

Integrative medicine research·2026

Same author

Clinical evidence on integrated Chinese-Western medicine for atopic dermatitis.

Integrative medicine research·2026

Same author

Perceived changes in sexual experience after voluntary medical male circumcision among men who have sex with men.

The journal of sexual medicine·2026

Search research articles

Related Experiment Video

Updated: Jun 28, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Association between white matter hyperintensity and anxiety/depression.

Ruixue Zhou¹, Qingqing Cai¹, Chen Liu¹

¹Key Laboratory of Trace Elements and Endemic Diseases, Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, P. R. China.

Cerebral Cortex (New York, N.Y. : 1991)

|April 11, 2024

Summary

This study found that increased white matter hyperintensity volume is linked to a higher risk of depression. Periventricular white matter hyperintensity was also associated with self-reported anxiety.

Keywords:

anxiety depression white matter hyperintensity

More Related Videos

Reducing State Anxiety Using Working Memory Maintenance

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Published on: November 11, 2022

Related Experiment Videos

Last Updated: Jun 28, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Reducing State Anxiety Using Working Memory Maintenance

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Published on: November 11, 2022

Area of Science:

Neuroimaging
Psychiatry
Epidemiology

Background:

Previous research on white matter hyperintensity (WMH) and psychiatric disorders has yielded inconsistent results due to small sample sizes.
Understanding the association between WMH and mental health is crucial for developing targeted interventions.

Purpose of the Study:

To systematically investigate the association between white matter hyperintensity volume and depression and anxiety in a large cohort.
To differentiate the impact of periventricular and deep white matter hyperintensity on psychiatric conditions.

Main Methods:

Utilized data from the UK Biobank, including general linear regression, logistic regression, and Cox proportional hazard models.
Assessed anxiety using the General Anxiety Disorder-7 score and self-report, and depression using the Patient Health Questionnaire-9 score and self-report.
Adjusted for multiple covariates including age, gender, BMI, lifestyle factors, and comorbidities.

Main Results:

White matter hyperintensity volume showed a significant association with both General Anxiety Disorder-7 and Patient Health Questionnaire-9 scores.
Periventricular white matter hyperintensity volume was significantly associated with self-reported anxiety.
Larger white matter hyperintensity volume, particularly periventricular, was linked to an increased risk of depression.

Conclusions:

Findings support a positive association between white matter hyperintensity volume and depression.
The study highlights the role of white matter integrity in the pathophysiology of depression.