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Medication persistence and its impact on type 2 diabetes.

Jee H Choe1, Si Xuan, Antony Goldenberg

  • 1Department of Pharmaceutical and Health Economics, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, 635 Downey Way, VPD 414C, Los Angeles, CA 90089-3333.

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Medication persistence in type 2 diabetes (T2D) is low, but improving it reduces hospitalizations and healthcare costs. Consistent treatment for T2D is vital for better patient outcomes and economic benefits.

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Area of Science:

  • Endocrinology
  • Pharmacoeconomics
  • Public Health

Background:

  • Medication persistence is crucial for managing type 2 diabetes (T2D) and preventing adverse events.
  • Understanding persistence rates and their impact is essential for optimizing T2D care.

Purpose of the Study:

  • To assess medication persistence in newly treated patients with type 2 diabetes.
  • To evaluate the impact of persistence on clinical outcomes and healthcare costs.

Main Methods:

  • Retrospective analysis of commercial and Medicare Advantage enrollees (2007-2020).
  • Identified adult patients initiating antidiabetic treatment with a prior treatment-free year.
  • Measured persistence as continuous therapy duration and analyzed factors influencing it, alongside hospitalization risk and costs.

Main Results:

  • Included 673,265 patients with a median follow-up of 7 years; only 22% maintained continuous treatment.
  • Each 1-month increase in duration reduced stroke, myocardial infarction, and all-cause hospitalization risks.
  • Increased duration correlated with decreased medical costs and increased drug costs.

Conclusions:

  • Low medication persistence is prevalent in type 2 diabetes management.
  • Enhancing medication persistence is associated with significant reductions in hospitalizations and overall healthcare expenditures.