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Published on: April 22, 2019
Lymphovascular Invasion in Cutaneous Squamous Cell Carcinoma
Michael P Ryan1, Frank T Winsett2, Andrew M Armenta2
1Department of Dermatology, University of Texas Health Science Center at Houston, Houston, Texas.
Background:
Although there is a large body of literature regarding risk stratification and outcomes for perineural invasion (PNI) in cutaneous squamous cell carcinoma (cSCC), there is a relative paucity of studies exploring the role of lymphovascular invasion (LVI) in cSCC and a lack of clear evidence-based guidelines for how to manage patients with these tumors.
Objective:
This article is intended to review the available literature regarding LVI in cSCC and formulate evidence-based recommendations for clinical management.
Methods And Materials:
A literature review was conducted using PubMed to find relevant articles relating to outcomes and management of primary cSCC with LVI.
Results:
The available literature suggests that LVI is a major risk factor for poor outcomes and increased morbidity and mortality in cSCC.
Conclusion:
Lymphovascular invasion is a very high-risk feature that should place these tumors in the highest-risk category, and management of these tumors should be similar to that of squamous cell carcinoma with PNI.
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