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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Lymphovascular Invasion In Cutaneous Squamous Cell Carcinoma.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Lymphovascular Invasion In Cutaneous Squamous Cell Carcinoma.

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Lymphovascular Invasion in Cutaneous Squamous Cell Carcinoma.

Michael P Ryan1, Frank T Winsett2, Andrew M Armenta2

  • 1Department of Dermatology, University of Texas Health Science Center at Houston, Houston, Texas.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|April 11, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Lymphovascular invasion (LVI) is a significant risk factor for poor outcomes in cutaneous squamous cell carcinoma (cSCC). Management of cSCC with LVI should align with high-risk tumors, similar to those with perineural invasion (PNI).

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Limited research exists on lymphovascular invasion (LVI) in cutaneous squamous cell carcinoma (cSCC).
  • Established literature on perineural invasion (PNI) in cSCC contrasts with the scarcity of data on LVI.
  • Lack of clear clinical management guidelines for cSCC with LVI.

Purpose of the Study:

  • To review existing literature on lymphovascular invasion (LVI) in cutaneous squamous cell carcinoma (cSCC).
  • To develop evidence-based recommendations for managing cSCC patients with LVI.

Main Methods:

  • A comprehensive literature review was performed.
  • PubMed database was utilized to identify relevant studies.
  • Focus on outcomes and management of primary cSCC with LVI.

Main Results:

  • Lymphovascular invasion (LVI) is identified as a major risk factor.
  • LVI is associated with poorer patient outcomes.
  • Increased morbidity and mortality linked to LVI in cSCC.

Conclusions:

  • Lymphovascular invasion (LVI) represents a high-risk feature in cSCC.
  • cSCC tumors with LVI should be classified in the highest-risk category.
  • Management strategies for LVI in cSCC should mirror those for PNI.