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Assessment of dietary intake and its inflammatory potential in persons with pediatric-onset multiple sclerosis

Sama Bitarafan1, Feng Zhu2, Ali Mirza2

  • 1Faculty of Medicine (Neurology), University of British Columbia and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Multiple Sclerosis and Related Disorders
|April 11, 2024
PubMed

Insights

Individuals with pediatric-onset multiple sclerosis (PoMS) consumed less whole grain than controls. Dietary inflammatory index did not significantly differ between groups, suggesting whole grains may play a role in PoMS.

Area of Science:

  • Neurology
  • Nutritional Science
  • Epidemiology

Background:

  • Pediatric-onset multiple sclerosis (PoMS) and monophasic acquired demyelinating syndromes (monoADS) are rare neurological conditions.
  • Dietary patterns and inflammation are implicated in multiple sclerosis (MS) pathogenesis.
  • Understanding dietary factors in pediatric neurological conditions is crucial for management.

Purpose of the Study:

  • To compare dietary intake and the modified dietary inflammatory index (mDII) in individuals with PoMS, monoADS, and healthy controls.
  • To investigate the association between diet, mDII, and disease status in pediatric neurological conditions.

Main Methods:

  • A cross-sectional study involving 131 participants (38 PoMS, 45 monoADS, 48 controls).
  • Dietary intake and mDII were assessed.
  • Logistic regression analysis was used to examine associations between diet, mDII, and disease status.

Main Results:

  • Individuals with PoMS showed a modest but significant association with lower whole grain intake compared to controls (aOR=0.964).
  • The modified dietary inflammatory index (mDII) was not significantly associated with PoMS in this cohort.
  • No significant dietary differences were found for individuals with monoADS compared to controls.

Conclusions:

  • Lower whole grain consumption is associated with pediatric-onset multiple sclerosis (PoMS).
  • Dietary inflammatory index did not differentiate between PoMS, monoADS, and controls.
  • Findings suggest a potential role for whole grains in the dietary management of PoMS.
Abstract

Keywords:
Case-control studyDietary intakeMonophasic acquired demyelinating syndromesMultiple sclerosisPediatricWhole grain

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