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Infectious diseases and the role of needle biopsy post-mortem
Lucia Molinengo1, Theodore Estrin-Serlui1, Brian Hanley2
1Cellular Pathology Department, Northwest London Pathology hosted by Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK.
The Lancet. Microbe
|April 11, 2024
Summary
Needle biopsy post-mortem offers a minimally invasive method for examining infectious diseases, crucial for public health and research when traditional autopsies are not feasible due to infection risks or cultural concerns.
Area of Science:
- Forensic pathology
- Infectious disease epidemiology
- Public health
Background:
- Post-mortem examinations are vital for understanding infectious disease spread and development.
- Infection risks associated with invasive autopsies can limit their use, especially for emerging diseases.
- Rapid acquisition of quality tissue samples is essential for public health responses.
Purpose of the Study:
- To review the evolution and applications of needle biopsy post-mortem.
- To highlight its utility in investigating endemic and emerging infectious diseases.
- To assess its role in overcoming barriers to traditional autopsy.
Main Methods:
- Review of literature on needle biopsy post-mortem techniques.
- Analysis of case studies and applications in infectious disease investigations.
- Evaluation of its minimally invasive and rapid characteristics.
Main Results:
- Needle biopsy post-mortem minimizes infection risk to practitioners.
- It facilitates tissue sampling in resource-limited settings and for culturally sensitive cases.
- The technique supports the investigation of both known and novel infectious agents.
Conclusions:
- Needle biopsy post-mortem is a valuable tool for infectious disease surveillance and research.
- Its minimally invasive nature makes it suitable for high-risk scenarios and diverse populations.
- The technique enhances the global capacity for post-mortem investigations in public health emergencies.

