Related Experiment Video
Updated: Jun 19, 2026
06:23
The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
Published on: October 13, 2016
32.3K
Predictors of post stroke cognitive impairment: VITATOPS cognition substudy
Isabel Siow1, Kaavya Narasimhalu2, Keng Siang Lee3
1Ministry of Health Holdings Singapore, Singapore.
Summary
Post-stroke cognitive impairment (PSCI) most commonly affects visuoconstruction and attention in Asian populations. Advanced age, lower education, and posterior circulation strokes are key predictors of PSCI.
Area of Science:
- Neurology
- Cognitive Science
- Stroke Research
Background:
- Post-stroke cognitive impairment (PSCI) is a frequent complication following ischemic stroke.
- Cognitive deficits in PSCI vary based on clinical and stroke-related factors.
- Identifying factors associated with specific cognitive domain impairments is crucial for targeted interventions.
Purpose of the Study:
- To determine factors associated with impairments in specific cognitive domains post-ischemic stroke.
- To analyze the prevalence and predictors of PSCI in an Asian cohort.
- To understand the relationship between stroke characteristics and cognitive decline.
Main Methods:
- Utilized data from the Vitamins to Prevent Stroke (VITATOPS) trial substudy.
- Included consecutive patients with ischemic stroke or transient ischemic attack (TIA) admitted to a tertiary hospital.
- Assessed six cognitive domains annually for up to five years using Cox proportional hazard models.
Main Results:
- 23.5% of 736 patients developed cognitive impairment.
- Visuoconstruction (26.4%) and attention (19.8%) were the most affected cognitive domains.
- Posterior circulation cerebral infarction (POCI), advanced age, Indian race, and lower education predicted specific cognitive impairments.
Conclusions:
- Visuoconstruction and attention domains are most impacted in this Asian PSCI cohort.
- Advanced age, lower education, posterior circulation strokes, and comorbidities are independent PSCI predictors.
- Findings highlight the need for tailored management strategies based on stroke type and patient demographics.
Related Concept Videos
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...