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Controlling Nutritional Status (CONUT) Score is Associated with Overall Survival in Patients with Hepatocellular Carcinoma Treated with Conventional Transcatheter Arterial Chemoembolization: A Propensity Score Matched Analysis

  • 0Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cardiovascular and Interventional Radiology +

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April 11, 2024

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April 11, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

A high Controlling Nutritional Status (CONUT) score indicates a poorer prognosis for overall survival in hepatocellular carcinoma patients undergoing chemoembolization. This finding highlights CONUT score as a valuable prognostic factor.

Area Of Science

  • Hepatology and Oncology
  • Interventional Radiology
  • Nutritional Assessment

Background

  • Hepatocellular carcinoma (HCC) is a primary liver malignancy with complex treatment strategies.
  • Conventional transcatheter arterial chemoembolization (cTACE) is a standard treatment for unresectable HCC.
  • Prognostic markers are crucial for tailoring treatment and predicting outcomes in HCC patients.

Purpose Of The Study

  • To investigate the prognostic significance of the Controlling Nutritional Status (CONUT) score in patients with HCC treated with cTACE.
  • To determine if the CONUT score can predict overall survival (OS) and progression-free survival (PFS) in this patient cohort.

Main Methods

  • Retrospective analysis of 936 HCC patients treated with cTACE from 2012-2018.
  • Propensity score matching (PSM) to balance baseline characteristics between low and high CONUT score groups.
  • Kaplan-Meier survival analysis, log-rank tests, and Cox proportional hazard models to assess OS and PFS.

Main Results

  • After PSM, a high CONUT score (≥4) was associated with significantly poorer median OS (17.0 months) compared to a low CONUT score (≤3) (22.2 months, P=0.014).
  • No significant difference in PFS was observed between the groups (P=0.121).
  • Cox regression identified a high CONUT score as an independent risk factor for OS (HR=1.361, P=0.022).

Conclusions

  • The CONUT score is a valuable and independent prognostic factor for overall survival in HCC patients undergoing cTACE.
  • A high CONUT score predicts worse outcomes, suggesting its utility in clinical decision-making and patient stratification.

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