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Updated: Jun 28, 2025
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Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
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Brimonidine as a possible treatment for myopia.
Zixuan Peng1,2, Aiqun Xiang1, Hong He3
1Hainan Provincial Key Laboratory of Ophthalmology, Hainan Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University, No. 19 Xiuhua Road, Xiuying District, 570300, Haikou, Hainan, China.
BMC Ophthalmology
|April 11, 2024
Summary
Brimonidine effectively treated form-deprivation myopia (FDM) in guinea pigs when administered via subconjunctival or intravitreal injection. This treatment reduced myopia, axial length, and intraocular pressure (IOP), highlighting its potential for myopia management.
Area of Science:
- Ophthalmology
- Pharmacology
- Preclinical Research
Background:
- Myopia represents a significant global public health challenge.
- Understanding the mechanisms and potential treatments for myopia is crucial.
Purpose of the Study:
- To investigate the efficacy of brimonidine in treating form-deprivation myopia (FDM).
- To explore the correlation between intraocular pressure (IOP) and myopia progression.
Main Methods:
- Form-deprivation myopia (FDM) was induced in guinea pigs.
- Brimonidine was administered through eye drops, subconjunctival injections, or intravitreal injections at various concentrations.
- Intraocular pressure (IOP), refractive error, and axial length (AL) were monitored over 21 days.
Main Results:
- Subconjunctival and intravitreal brimonidine significantly inhibited FDM development.
- Effective treatments reduced myopic refraction, axial elongation, and elevated IOP.
- Ophthalmic brimonidine eye drops showed no efficacy in treating FDM.
Conclusions:
- Brimonidine, at specific doses and administration routes, can effectively reduce FDM development in a preclinical model.
- Intraocular pressure (IOP) fluctuations may be associated with the progression of form-deprivation myopia.
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