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Updated: Jun 28, 2025

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Correlation between acne and insulin resistance; experience from central India
Prachi R Srivastava1, Jaideep Khare2, Animesh Saxena1
1Department of Dermatology, People's College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
This study found that 42.67% of acne patients exhibit insulin resistance. This suggests potential new treatments for acne and highlights the importance of managing metabolic syndrome risk factors in acne patients.
Area of Science:
- Dermatology
- Endocrinology
- Metabolic Health
Background:
- Acne vulgaris is a common skin condition affecting adolescents and adults.
- Its pathogenesis involves keratinocyte proliferation, abnormal desquamation, and metabolic factors.
- Insulin resistance is increasingly recognized as a potential contributor to acne development.
Purpose of the Study:
- To investigate the causal relationship between acne vulgaris and insulin resistance.
- To quantify insulin resistance using Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).
- To determine the correlation between insulin resistance and acne severity.
Main Methods:
- A retrospective analysis of 150 patients with persistent acne vulgaris referred for endocrine evaluation.
- Exclusion of patients with known hormonal or metabolic abnormalities causing acne.
- Calculation of HOMA-IR for all included patients.
Main Results:
- The mean HOMA-IR in acne patients was 1.62 (range: 0.9-3.7).
- Insulin resistance (HOMA-IR > 2.0) was identified in 64 (42.67%) patients.
- The male-to-female ratio was 23:27, with a mean age of 33.2 years.
Conclusions:
- A significant prevalence of insulin resistance (42.67%) was observed in patients with acne vulgaris.
- Insulin resistance may be a modifiable factor in acne pathogenesis.
- Findings suggest exploring insulin-modifying agents and lifestyle changes for acne management and metabolic syndrome risk stratification.
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