Film dressings from Thai mango seed kernel extracts versus nanocrystalline silver dressings in antibacterial
Sukhontha Hasatsri1, Bajaree Jantrapanukorn2
1Department of Pharmacy Practice, College of Pharmacy, Rangsit University, Pathum Thani, Thailand.
Abstract:
Introduction: The extract from the Mango Seed Kernel (MSK) has been documented to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. This suggests that biomaterials containing MSK extract could be a viable alternative to conventional wound treatments, such as nanocrystalline silver dressings. Despite this potential, there is a notable gap in the literature regarding comparing the antibacterial effectiveness of MSK film dressings with nanocrystalline silver dressings. This study aimed to develop film dressings containing MSK extract and evaluate their antibacterial properties compared to nanocrystalline silver dressings. Additionally, the study aimed to assess other vital physical properties of these dressings critical for effective wound care. Materials and methods: We prepared MSK film dressings from two cultivars of mango from Thailand, 'Chokanan' and 'Namdokmai'. The inhibition-zone method was employed to determine the antibacterial property. The morphology and chemical characterization of the prepared MSK film dressings were examined with scanning electron microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR), respectively. The absorption of pseudo-wound exudate and water vapor transmission rate (WVTR) of film dressings were evaluated. Results: The results showed that 40% of MSKC film dressing had the highest inhibition zone (20.00 ± 0.00 mm against S. aureus and 17.00 ± 1.00 mm against P. aeruginosa) and 20%, 30%, and 40% of MSKC and MSKN film dressings had inhibition zones similar to nanocrystalline silver dressing for both S. aureus and P. aeruginosa (p > 0.05). In addition, all concentrations of the MSK film dressings had low absorption capacity, and Chokanan MSK (MSKC) film dressings had a higher WVTR than Namdokmai MSK (MSKN) film dressings. Conclusion: 20%, 30%, and 40% of MSK film dressing is nearly as effective as nanocrystalline silver dressing. Therefore, it has the potential to be an alternative antibacterial dressing and is suitable for wounds with low exudate levels.
Insights
Mango Seed Kernel (MSK) film dressings show comparable antibacterial effectiveness to silver dressings against common wound bacteria. These novel MSK dressings are a promising alternative for low-exudate wound care.
Area of Science:
- Biomaterials Science
- Wound Care Innovations
- Natural Product Chemistry
Background:
- Mango Seed Kernel (MSK) extract possesses documented antibacterial properties against Gram-positive and Gram-negative bacteria.
- Conventional wound treatments like nanocrystalline silver dressings are effective but may have limitations.
- A research gap exists in comparing MSK film dressings with established antibacterial wound care products.
Purpose of the Study:
- To develop film dressings incorporating MSK extract.
- To evaluate the antibacterial efficacy of MSK film dressings against Staphylococcus aureus and Pseudomonas aeruginosa.
- To assess key physical properties of MSK film dressings relevant to wound healing.
Main Methods:
- MSK film dressings were prepared from two Thai mango cultivars: 'Chokanan' (MSKC) and 'Namdokmai' (MSKN).
- Antibacterial activity was determined using the inhibition-zone method.
- Morphology (SEM), chemical characterization (FTIR), exudate absorption, and water vapor transmission rate (WVTR) were evaluated.
Main Results:
- MSK film dressings at 20%, 30%, and 40% concentrations exhibited inhibition zones comparable to nanocrystalline silver dressings for both S. aureus and P. aeruginosa.
- The 40% MSKC dressing showed the largest inhibition zones.
- All MSK film dressings demonstrated low absorption capacity, with MSKC showing higher WVTR than MSKN.
Conclusions:
- MSK film dressings (20-40%) present comparable antibacterial effectiveness to nanocrystalline silver dressings.
- These MSK dressings show potential as an alternative antibacterial option for wound management.
- The developed dressings are particularly suitable for wounds characterized by low levels of exudate.
