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MicroRNA‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)

Woohyeong Jung1, Uijin Juang1, Suhwan Gwon1

  • 1Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.

Molecular Medicine Reports
|April 12, 2024
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in muscle stability. Understanding their role in muscular atrophy can lead to new treatments for muscle loss.

Area of Science:

  • Molecular Biology
  • Genetics
  • Physiology

Background:

  • Muscular atrophy, characterized by loss of muscle mass and strength, is a critical issue in various diseases.
  • MicroRNAs (miRNAs) are crucial gene expression regulators involved in maintaining muscle stability.
  • Dysregulation of miRNAs significantly contributes to muscular atrophy development.

Approach:

  • This review synthesizes current research on miRNA expression patterns in muscular atrophy.
  • It elucidates the complex regulatory networks involving miRNAs in muscle homeostasis.
  • The review examines signaling pathways like protein kinase B/mTOR and ubiquitin-proteasome systems.

Key Points:

  • miRNAs play a vital role in regulating muscle protein synthesis, breakdown, and regeneration.
  • Specific miRNA dysregulation is linked to pathological muscle wasting.
  • Autophagy and inflammatory signaling pathways are also implicated in muscular atrophy.

Conclusions:

  • A comprehensive understanding of miRNA networks is essential for developing targeted therapies for muscular atrophy.
  • This review provides a foundation for novel therapeutic strategies to prevent or reverse muscle loss.
  • Further research into multifaceted regulatory pathways will enhance treatment efficacy.
Keywords:
biomarkermicroRNAsmolecular pathwaymuscle regenerationmuscular atrophysarcopenia

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