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Acinetobacter junii: an emerging One Health pathogen.

Alejandro Aguilar-Vera1, Elena Bello-López1, Gabriel Iván Pantoja-Nuñez2

  • 1Programa de Genómica Evolutiva, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, México.

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Acinetobacter junii, an understudied pathogen, has spread globally and is found in both humans and animals. Some strains carry crucial antibiotic resistance genes, highlighting a One Health concern.

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Area of Science:

  • Microbiology
  • Genomics
  • Epidemiology

Background:

  • Acinetobacter junii is an opportunistic pathogen in humans and animals, yet it remains understudied.
  • While Acinetobacter baumannii is well-known, other Acinetobacter species may also pose significant health risks.

Purpose of the Study:

  • To conduct the largest genomic epidemiological study of Acinetobacter junii to date.
  • To investigate the global spread and transmission dynamics of A. junii between human and non-human hosts.

Main Methods:

  • Genomic sequencing and phylogenetic analysis of A. junii isolates.
  • Comparative analysis of human and non-human isolates to assess genetic relatedness.

Main Results:

  • Acinetobacter junii has a global distribution.
  • Human and non-human isolates of A. junii are not always well-differentiated, suggesting inter-species transmission.
  • Clinically relevant antibiotic resistance genes were found in both human and non-human isolates, with some located on plasmids.

Conclusions:

  • Acinetobacter junii should be recognized as an emerging One Health issue.
  • Future research should include environmental and animal reservoirs in molecular epidemiology studies of A. junii.
  • The findings support considering A. junii as a pathogen relevant to both human and veterinary medicine.