Colorectal Adenosquamous Carcinoma: Demographics, Tumor Characteristics, and Survival Benefits of Surgery with Chemoradiation.

Area of Science:

• Oncology
• Gastroenterology
• Pathology

Background:

• Colorectal adenosquamous carcinoma (ASC) is a rare and aggressive subtype of colorectal cancer.
• Understanding its unique demographic, clinical, and pathological characteristics is crucial for improving patient outcomes.

Purpose of the Study:

• To analyze demographic, clinical, and pathological factors influencing prognosis and survival in colorectal ASC.
• To identify predictors of overall survival (OS) and cause-specific survival (CSS) in a large patient cohort.

Main Methods:

• Utilized the Surveillance, Epidemiology, and End Results (SEER) database for colorectal ASC cases diagnosed between 2000 and 2020.
• Conducted multivariate analysis to assess factors associated with OS and CSS.

Main Results:

• Median age at diagnosis was 64 years; predominantly diagnosed in White individuals with lower income and in metropolitan areas.
• Tumors were often poorly differentiated, regionally staged, larger than 4.0 cm, and frequently located in the colon.
• Five-year OS was 31.3% and CSS was 40.1%. Age ≥ 60, regional, and distant stages were negative prognostic factors; higher income, multimodal therapy, and surgery with chemotherapy were positive factors.

Conclusions:

• Colorectal ASC predominantly affects non-Hispanic White populations later in life.
• Age ≥ 60, regional, and distant stages are associated with poorer prognosis.
• Higher income and specific treatment modalities (multimodal therapy, surgery + chemotherapy) correlate with improved survival outcomes.