Related Experiment Video
Updated: Jun 22, 2026
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Cognitive assessment during the phases of a spontaneous migraine: a prospective cohort study
Jason C Ray1,2,3, David Darby4,5, Helmut Butzkueven4,5
1Department of Neurology, Alfred Hospital, Commercial Road, Melbourne, VIC, 3004, Australia. Jason.Ray@monash.edu.
Introduction:
Cognitive symptoms are reported commonly throughout all phases of a migraine; however, there is a paucity of objective cognitive profiling. Previous studies have been limited by practice effect, and variable populations.
Methods:
Participants completed 1 month of daily testing with a computerised cognitive battery involving a simple reaction (SRT), choice reaction (CRT) and a working memory test (WM). Results were correlated with their diary to identify interictal scores, and scores during each phase of a migraine, and non-migraine headache days.
Results:
A total of 16 patients with episodic migraine participated. During the headache phase of a migraine, responses to SRT, CRT and WM tasks were significantly slower and less accurate than interictally. During the postdrome, WM task performance was slower and less accurate. Non-migraine headache days were not associated with significant change.
Conclusion:
The headache and postdromal phase of a migraine day was associated with objective evidence of cognitive dysfunction in patients with episodic migraine.
