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A spouse’s cardiovascular disease (CVD) diagnosis increases an individual’s risk of developing depression. This highlights the need for mental health support for partners of those with CVD.

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Area of Science:

  • Public Health
  • Epidemiology
  • Mental Health Research

Background:

  • Cardiovascular disease (CVD) is a known risk factor for depression.
  • Limited evidence exists on the impact of a spouse's CVD on an individual's subsequent mental health.

Purpose of the Study:

  • To investigate the association between the onset of cardiovascular disease (CVD) in one spouse and the subsequent risk of depression in the other spouse.

Main Methods:

  • A nationwide cohort study of 277,142 matched married couples in Japan.
  • Used Cox proportional hazards models to analyze the association between spousal CVD onset and individual depression.
  • Adjusted for sociodemographic factors, comorbidities, and health behaviors.

Main Results:

  • An increased risk of depression was observed in individuals whose spouses experienced incident CVD (HR, 1.13; 95% CI, 1.07-1.20).
  • Results remained consistent after adjusting for health behaviors and physical health conditions (HR, 1.16; 95% CI, 1.06-1.28).
  • No significant heterogeneity was found across subgroups based on sex, age, income, or prior CVD history.

Conclusions:

  • Spousal onset of cardiovascular disease is associated with a higher risk of depression in individuals.
  • Highlights the importance of integrated mental health care for individuals supporting a spouse with CVD.