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Updated: Jun 28, 2025
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Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
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Ultrasound elastography predicts anticoagulation in lower extremity deep vein thrombosis
Ao-Yi Zhang1, Ya-Xin Dong1, Yan-Di Tan1
1Department of Ultrasound, the First Clinical Medical Science College of China Three Gorges University and Yichang Central People's Hospital, Yi chang, Hubei, China.
Clinical Hemorheology and Microcirculation
|April 12, 2024
Summary
Ultrasound elastography can predict anticoagulation effectiveness in deep venous thrombosis (DVT). Elastic modulus and strain rate ratio of thrombi are key predictors for successful DVT treatment.
Area of Science:
- Vascular Medicine
- Medical Imaging
- Biophysics
Background:
- Deep venous thrombosis (DVT) poses significant risks, necessitating effective anticoagulation therapy.
- Assessing anticoagulation efficacy is crucial for patient outcomes and preventing complications.
- Current methods for evaluating DVT treatment effectiveness have limitations.
Purpose of the Study:
- To identify predictors of anticoagulation efficacy in DVT using ultrasound elastography (UE).
- To determine if UE parameters can forecast successful anticoagulation treatment in DVT patients.
Main Methods:
- Collected clinical, laboratory, and ultrasound data from 58 DVT patients.
- Analyzed ultrasound results after 3-month anticoagulation treatment.
- Employed multiple logistic regression and ROC curves to identify and assess independent risk factors.
Main Results:
- Elastic modulus (OR=0.631, P=0.001) and strain rate ratio (OR=0.332, P=0.006) were independent predictors of anticoagulation effectiveness.
- Optimal thresholds for elastic modulus (22.10 kPa) and strain rate ratio (1.80) showed high predictive value (AUC 0.879 and 0.854, respectively).
Conclusions:
- Thrombus elastic modulus (≤22.10 kPa) and strain rate ratio (≤1.80) independently predict successful anticoagulation therapy in DVT.
- Ultrasound elastography offers a valuable tool for monitoring and predicting DVT treatment outcomes.
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