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Sparse Asymmetry in Locus Coeruleus Pathology in Alzheimer's Disease

Elise Beckers^1,2, Joost M Riphagen^3,4, Maxime Van Egroo¹

¹Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.

Journal of Alzheimer'S Disease : JAD

|April 12, 2024

Abstract:

Tau accumulation in and neurodegeneration of locus coeruleus (LC) neurons is observed in Alzheimer's disease (AD). We investigated whether tangle and neuronal density in the rostral and caudal LC is characterized by an asymmetric pattern in 77 autopsy cases of the Rush Memory and Aging Project. We found left-right equivalence for tangle density across individuals with and without AD pathology. However, neuronal density, particularly in the caudal-rostral axis of the LC, is asymmetric among individuals with AD pathology. Asymmetry in LC neuronal density may signal advanced disease progression and should be considered in AD neuroimaging studies of LC neurodegeneration.

Keywords:

Alzheimer’s disease asymmetry autopsy brainstem locus coeruleus neurons tangles

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