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Related Experiment Video

Updated: Jun 28, 2025

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb
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Postural behaviour in people with multiple sclerosis: A complexity paradox.

L Eduardo Cofré Lizama1, Maya G Panisset1, Liuhua Peng2

  • 1Department of Medicine, The University of Melbourne, Parkville, VIC 3050, Australia.

Gait & Posture
|April 12, 2024
PubMed
Summary
This summary is machine-generated.

Postural behavior complexity decreases in people with multiple sclerosis (pwMS) as tasks become more challenging, especially with eyes closed on compliant surfaces. This finding suggests reduced sensorimotor adaptability in early MS and highlights complexity index as a potential early biomarker.

Keywords:
BalanceEntropySensorimotor integrationSensory weightingStability

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Area of Science:

  • Neurology
  • Biomedical Engineering
  • Human Movement Science

Background:

  • Balance deficits are a significant challenge for people with multiple sclerosis (pwMS).
  • Assessing motor behavior complexity offers insights into the adaptability of the balance control system in MS.
  • Understanding these changes is crucial for managing MS-related functional impairments.

Purpose of the Study:

  • To determine if postural behavior complexity differs between early-stage pwMS and healthy controls (HC).
  • To investigate how postural behavior complexity changes across tasks of increasing difficulty.
  • To explore the potential of complexity index (CI) as a biomarker for MS.

Main Methods:

  • Forty-eight pwMS and 24 HC completed four increasingly complex postural tasks under various conditions (eyes open/closed, firm/compliant surfaces).
  • 3D acceleration data were collected using lumbar and sternum sensors.
  • Complexity Index (CI) was calculated using multiscale sample entropy (MSE) in frontal and sagittal planes.

Main Results:

  • A significantly lower CI was observed in pwMS compared to HC during the eyes-closed, compliant-surface task (EC-CS).
  • In pwMS, CI was significantly reduced during the EC-CS task compared to other tasks, irrespective of sensor location.
  • These findings indicate a specific challenge to balance control in pwMS under demanding sensory conditions.

Conclusions:

  • Increased postural task complexity paradoxically reduces postural behavior complexity in pwMS.
  • This reduction may indicate impaired sensorimotor integration adaptability in early MS.
  • CI shows promise as a sensitive biomarker for MS progression and early detection of balance deficits.