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Photoluminescence: Applications01:14

Photoluminescence: Applications

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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
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  11. Bridging Biological And Food Monitoring: A Colorimetric And Fluorescent Dual-mode Sensor Based On N-doped Carbon Dots For Detection Of Ph And Histamine.
  1. Home
  3. Research Domains
  5. Chemical Sciences
  7. Macromolecular And Materials Chemistry
  9. Nanochemistry
  11. Bridging Biological And Food Monitoring: A Colorimetric And Fluorescent Dual-mode Sensor Based On N-doped Carbon Dots For Detection Of Ph And Histamine.

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Bridging biological and food monitoring: A colorimetric and fluorescent dual-mode sensor based on N-doped carbon dots for detection of pH and histamine.

Xiaoran Zhang1, Jing Wang1, Elias Hasan1

  • 1College of Chemistry and Chemical Engineering, Institute of Environmental Science, Shanxi University, Taiyuan 030006, PR China.

Journal of Hazardous Materials
|April 12, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Carbon dotsDual-modal sensingFood freshnessIntracellular pH monitoring

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N-doped carbon dots (CDs) offer dual-mode sensing for pH and histamine, enabling precise cell analysis and food freshness monitoring. This versatile biosensor integrates with smartphones for portable, visual detection.

Area of Science:

  • Nanomaterials Science
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Accurate pH and histamine monitoring is vital for biological and food systems.
  • Existing methods often lack sensitivity or dual-mode capabilities for comprehensive analysis.
  • N-doped carbon dots (CDs) present a promising platform for advanced sensing applications.

Purpose of the Study:

  • To develop N-doped carbon dots (CDs) for sensitive, dual-mode detection of pH and histamine.
  • To explore the application of these CDs in differentiating between normal and cancerous cells.
  • To establish a portable sensing platform for real-time food freshness evaluation.

Main Methods:

  • Fabrication of N-doped carbon dots (CDs) via a hydrothermal method using dipicolinic acid and o-phenylenediamine.
Smartphone-integrated sensor
  • Utilizing aggregation-induced emission enhancement and intramolecular charge transfer for sensing mechanisms.
  • Integrating the developed CDs with a smartphone for colorimetric and fluorescent signal readout.

    • Main Results:

    • CDs demonstrated distinct colorimetric and fluorescent responses to pH variations, enabling cancer cell differentiation.
    • The pH-responsive CDs effectively monitored histamine levels in food with broad linearity ranges (25-1000 µM and 30-1000 µM).
    • A smartphone-integrated platform provided portable and visual detection of both pH and histamine.

    Conclusions:

    • N-doped carbon dots offer a versatile platform for simultaneous pH and histamine monitoring in biological and food samples.
    • The developed sensor provides a novel, portable, and sensitive approach for environmental and biosensing applications.
    • This technology bridges biological and food systems, enabling identification of abnormal conditions with high accuracy.