ASSOCIATION OF MPV AND RDW WITH DISEASE ACTIVITY IN PATIENT WITH RHEUMATOID ARTHRITIS

Area of Science:

• Rheumatology
• Clinical Immunology
• Hematology

Background:

• Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation.
• Accurate assessment of RA disease activity is vital for effective treatment and monitoring.
• Biomarkers for disease activity assessment are continuously sought.

Purpose of the Study:

• To investigate the association between Mean Platelet Volume (MPV), Red Cell Distribution Width (RDW), and disease activity in RA patients.
• To evaluate the potential of MPV and RDW as accessible markers for RA disease activity.

Main Methods:

• A cohort of 100 RA patients was studied.
• Disease activity was assessed using the Disease Activity Score 28 (DAS28).
• Blood tests were performed to measure MPV and RDW levels, with established cut-off points.

Main Results:

• A significant association was found between RDW levels and DAS28 scores in RA patients.
• Patients with RDW ≤14.8% exhibited higher DAS28 scores compared to those with RDW >14.8%.
• MPV levels did not show a statistically significant variation concerning disease activity.

Conclusions:

• RDW is significantly correlated with rheumatoid arthritis disease activity.
• RDW presents a potential, cost-effective biomarker for monitoring RA disease activity in clinical practice.
• MPV is not a significant indicator of disease activity in this RA cohort.