Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

166
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
166
Cognitive Development During Adolescence01:18

Cognitive Development During Adolescence

54
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
54
Understanding Sleep01:11

Understanding Sleep

228
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
228
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

182
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
182
Socioemotional Development during Infancy01:30

Socioemotional Development during Infancy

54
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
54
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

141
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
141

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural responses to equity and inequity when receiving vicarious rewards for self and charity during adolescence.

NeuroImage·2026
Same author

Adolescent Hormonal Contraceptive Use in the Context of Brain Development and Depression Risk: A Review and Considerations for Future Research.

Biological psychiatry global open science·2026
Same author

Does variation in the μ-opioid receptor gene (OPRM1) moderate the association between maternal sensitivity and child attachment? A preregistered attempted replication and extension of Tchalova et al. (2024).

Attachment & human development·2026
Same author

Youth Perspectives on the Climate Crisis: Motivation and Action Pathways.

Developmental science·2026
Same author

Neural variability across the transition to motherhood: Enhanced moment-to-moment neural variability during mentalizing in first-time mothers.

Journal of neuroendocrinology·2026
Same author

Mood trajectories showing resilience and recovery in young people during and after the COVID-19 pandemic.

Scientific reports·2026

Related Experiment Video

Updated: Jun 28, 2025

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

11.9K

Mood variability during adolescent development and its relation to sleep and brain development.

Yara J Toenders1,2,3, Renske van der Cruijsen4, Jana Runze5

  • 1Developmental and Educational Psychology, Leiden University, Wassenaarseweg 52, 2333 AK, Leiden, The Netherlands. y.j.toenders@fsw.leidenuniv.nl.

Scientific Reports
|April 12, 2024
PubMed
Summary

Mood variability in adolescents is linked to brain structure, not sleep. Delayed thinning in the dorsolateral prefrontal cortex (dlPFC) correlated with increased negative mood swings during adolescence.

Keywords:
ActigraphyAdolescenceAnxietyBrain structureDepressionMood variabilitySleep

More Related Videos

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

10.1K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

673

Related Experiment Videos

Last Updated: Jun 28, 2025

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

11.9K
Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

10.1K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

673

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Adolescent Psychiatry

Background:

  • Mood variability is linked to adverse mental health outcomes.
  • Adolescence is a critical period for mood disorder onset.
  • Understanding biological factors like sleep and brain development is key to elucidating mood disorder mechanisms.

Purpose of the Study:

  • To investigate the association between sleep, brain structure, and mood variability in healthy adolescents.
  • To examine developmental trajectories of mood variability and related factors.

Main Methods:

  • Longitudinal study (5 yearly timepoints) of 191 healthy adolescents (aged 11-21 at baseline).
  • Sleep assessed via actigraphy (objective) and daily diary (subjective).
  • Negative mood variability measured as day-to-day negative mood swings; brain structure analyzed using MRI, focusing on dorsolateral prefrontal cortex (dlPFC) thickness.

Main Results:

  • Negative mood variability peaked in mid-adolescence for females and linearly increased in males.
  • Sleep duration decreased across adolescence, with a more significant decline in males.
  • No association found between mood variability and sleep; average negative mood linked to lower energy.
  • Higher dlPFC thickness (delayed thinning) associated with increased negative mood variability in early to mid-adolescence.

Conclusions:

  • Mood variability development differs between adolescent males and females.
  • Brain structure, specifically dlPFC maturation, is associated with mood variability.
  • Sleep does not appear to be a direct correlate of mood variability in this adolescent cohort.